.rna-intro[data-astro-cid-5rpt6v6s]{background:var(--pre-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.75rem;flex-direction:column;gap:.75rem;padding:1rem;display:flex}.panel[data-astro-cid-5rpt6v6s]{background:var(--body-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.5rem;padding:.875rem}.panel-title[data-astro-cid-5rpt6v6s]{color:var(--body-color);justify-content:space-between;align-items:baseline;display:flex;padding:0 0 .75rem!important;font-size:.75rem!important;font-weight:560!important}.panel-title[data-astro-cid-5rpt6v6s] span[data-astro-cid-5rpt6v6s]{color:var(--muted);font-variant-numeric:tabular-nums;font-weight:460}.sequence[data-astro-cid-5rpt6v6s]{font-family:var(--font-code);flex-wrap:wrap;display:flex;letter-spacing:.06em!important;padding:0!important;font-size:.75rem!important;line-height:1.5!important}.sequence[data-astro-cid-5rpt6v6s] span[data-astro-cid-5rpt6v6s]{color:var(--soft);cursor:default;border-radius:2px}.sequence[data-astro-cid-5rpt6v6s] span[data-astro-cid-5rpt6v6s][data-lit]{color:var(--body-bg);background:var(--trace)}.view[data-astro-cid-5rpt6v6s]{aspect-ratio:1;cursor:grab;touch-action:none;width:100%;max-width:18rem;height:auto;margin:0 auto;display:block;overflow:visible}.view[data-astro-cid-5rpt6v6s]:active{cursor:grabbing}.rna-intro[data-astro-cid-5rpt6v6s]{--trace:#2a78d6}:root[data-theme=dark] .rna-intro[data-astro-cid-5rpt6v6s]{--trace:#3987e5}.view[data-astro-cid-5rpt6v6s] .seg{stroke:var(--trace);stroke-width:.7px;stroke-linecap:round}.view[data-astro-cid-5rpt6v6s] .dot{fill:var(--trace);stroke:var(--body-bg);stroke-width:.3px}.view[data-astro-cid-5rpt6v6s] .dot.lit{fill:var(--body-color);r:2.4px}.template-gap[data-astro-cid-ghgzwwfg]{--target:42, 120, 214;--template:235, 104, 52;background:var(--pre-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.75rem;padding:1rem}:root[data-theme=dark] .template-gap[data-astro-cid-ghgzwwfg]{--target:57, 135, 229;--template:217, 89, 38}[data-astro-cid-ghgzwwfg][data-role=target]{--tone:var(--target)}[data-astro-cid-ghgzwwfg][data-role=template]{--tone:var(--template)}.panels[data-astro-cid-ghgzwwfg]{flex-direction:column;gap:.75rem;display:flex}.panel[data-astro-cid-ghgzwwfg]{background:var(--body-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.5rem;flex-direction:column;padding:.875rem;display:flex}.panel-title[data-astro-cid-ghgzwwfg]{color:var(--body-color);justify-content:space-between;align-items:center;gap:.5rem;display:flex;padding:0 0 .75rem!important;font-size:.75rem!important;font-weight:560!important}.seqs[data-astro-cid-ghgzwwfg]{flex-direction:column;flex:1;justify-content:center;gap:.5rem;display:flex}.seq-row[data-astro-cid-ghgzwwfg]{align-items:baseline;gap:.75rem;display:flex}.id[data-astro-cid-ghgzwwfg]{color:rgb(var(--tone));flex:0 0 2.25rem;font-size:.6875rem;font-weight:560}.letters[data-astro-cid-ghgzwwfg]{font-family:var(--font-code);letter-spacing:.08em;color:var(--soft);flex-wrap:wrap;font-size:.75rem;line-height:1.5;display:flex}.letters[data-astro-cid-ghgzwwfg] [data-astro-cid-ghgzwwfg][data-same]{color:var(--body-color);background:var(--code-bg);border-radius:2px}.toggles[data-astro-cid-ghgzwwfg]{justify-content:center;gap:.375rem;padding-top:.5rem;display:flex}.toggles[data-astro-cid-ghgzwwfg] button[data-astro-cid-ghgzwwfg]{color:var(--body-color);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:1rem;align-items:center;gap:.25rem;padding:.125rem .375rem;font-size:.6875rem;font-weight:500;transition:opacity .15s;display:flex}.toggles[data-astro-cid-ghgzwwfg] button[data-astro-cid-ghgzwwfg][aria-pressed=false]{opacity:.45}.toggles[data-astro-cid-ghgzwwfg] button[data-astro-cid-ghgzwwfg]:focus-visible{outline:2px solid var(--focus-color);outline-offset:1px}.swatch[data-astro-cid-ghgzwwfg]{background:rgb(var(--tone));border-radius:50%;width:.5rem;height:.5rem}.view[data-astro-cid-ghgzwwfg]{aspect-ratio:1;cursor:grab;touch-action:none;width:100%;max-width:18rem;height:auto;margin:0 auto;display:block;overflow:visible}.view[data-astro-cid-ghgzwwfg]:active{cursor:grabbing}.view[data-astro-cid-ghgzwwfg] .seg{stroke-width:.8px;stroke-linecap:round}.view[data-astro-cid-ghgzwwfg] .target{stroke:rgb(var(--target));fill:rgb(var(--target))}.view[data-astro-cid-ghgzwwfg] .template{stroke:rgb(var(--template));fill:rgb(var(--template))}.view[data-astro-cid-ghgzwwfg] .dot{stroke:var(--body-bg);stroke-width:.3px}.score[data-astro-cid-ghgzwwfg]{box-shadow:inset 0 1px 0 var(--hairline);justify-content:space-between;align-items:baseline;margin-top:.75rem;padding-top:.625rem;display:flex}.score[data-astro-cid-ghgzwwfg] dt[data-astro-cid-ghgzwwfg]{color:var(--muted);font-size:.6875rem;font-weight:500}.score[data-astro-cid-ghgzwwfg] dd[data-astro-cid-ghgzwwfg]{color:var(--body-color);font-variant-numeric:tabular-nums;font-size:1rem;font-weight:600}@media (width<=560px){.seq-row[data-astro-cid-ghgzwwfg]{flex-direction:column;gap:.125rem}}.slope[data-astro-cid-vin7bwvf]{--primary:42, 120, 214;--john:235, 104, 52;--side:27, 175, 122;background:var(--pre-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.75rem;padding:1rem}:root[data-theme=dark] .slope[data-astro-cid-vin7bwvf]{--primary:57, 135, 229;--john:217, 89, 38;--side:25, 158, 112}[data-astro-cid-vin7bwvf][data-method=primary]{--tone:var(--primary)}[data-astro-cid-vin7bwvf][data-method=john]{--tone:var(--john)}[data-astro-cid-vin7bwvf][data-method=side]{--tone:var(--side)}.legend[data-astro-cid-vin7bwvf]{flex-wrap:wrap;gap:.375rem 1rem;padding-bottom:.75rem;display:flex}.legend[data-astro-cid-vin7bwvf] li[data-astro-cid-vin7bwvf]{color:var(--soft);cursor:default;outline:none;align-items:center;gap:.375rem;font-size:.75rem;font-weight:460;transition:opacity .15s;display:flex}.legend[data-astro-cid-vin7bwvf] li[data-astro-cid-vin7bwvf]:focus-visible{outline:2px solid var(--focus-color);outline-offset:2px;border-radius:2px}.swatch[data-astro-cid-vin7bwvf]{background:rgb(var(--tone));border-radius:1px;width:.75rem;height:2px}.tag[data-astro-cid-vin7bwvf]{color:var(--muted);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:1rem;padding:0 .3125rem;font-size:.625rem}svg[data-astro-cid-vin7bwvf]{width:100%;height:auto;display:block;overflow:visible}.tick[data-astro-cid-vin7bwvf] line[data-astro-cid-vin7bwvf]{stroke:var(--hairline);stroke-width:1px}.tick[data-astro-cid-vin7bwvf] text[data-astro-cid-vin7bwvf],.col[data-astro-cid-vin7bwvf]{fill:var(--muted);font-variant-numeric:tabular-nums;font-size:10px;font-weight:460}.tick[data-astro-cid-vin7bwvf] text[data-astro-cid-vin7bwvf]{text-anchor:end}.col[data-astro-cid-vin7bwvf]{text-anchor:middle;fill:var(--soft);font-size:11px;font-weight:500}.line[data-astro-cid-vin7bwvf]{fill:none;stroke:rgb(var(--tone));stroke-width:2px;stroke-linejoin:round;stroke-linecap:round}.hit[data-astro-cid-vin7bwvf]{fill:none;stroke:#0000;stroke-width:14px;pointer-events:stroke}.series[data-astro-cid-vin7bwvf] circle[data-astro-cid-vin7bwvf]{fill:rgb(var(--tone));stroke:var(--pre-bg);stroke-width:2px}.series[data-astro-cid-vin7bwvf],.legend[data-astro-cid-vin7bwvf] li[data-astro-cid-vin7bwvf]{transition:opacity .15s}.value[data-astro-cid-vin7bwvf]{fill:var(--body-color);font-variant-numeric:tabular-nums;text-anchor:middle;opacity:0;pointer-events:none;font-size:10px;font-weight:560;transition:opacity .15s}.value[data-astro-cid-vin7bwvf][data-end]{text-anchor:start}.slope[data-astro-cid-vin7bwvf][data-focus] .series[data-astro-cid-vin7bwvf]:not([data-on]),.slope[data-astro-cid-vin7bwvf][data-focus] .legend[data-astro-cid-vin7bwvf] li[data-astro-cid-vin7bwvf]:not([data-on]){opacity:.25}.series[data-astro-cid-vin7bwvf][data-on] .value[data-astro-cid-vin7bwvf]{opacity:1}.picker[data-astro-cid-muwqkpis]{--pick:42, 120, 214;background:var(--pre-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.75rem;padding:1rem}:root[data-theme=dark] .picker[data-astro-cid-muwqkpis]{--pick:57, 135, 229}.controls[data-astro-cid-muwqkpis]{align-items:flex-end;gap:1rem;display:flex}label[data-astro-cid-muwqkpis]{flex-direction:column;flex:1;gap:.375rem;display:flex}label[data-astro-cid-muwqkpis]>span[data-astro-cid-muwqkpis]{color:var(--soft);justify-content:space-between;font-size:.75rem;font-weight:460;display:flex}output[data-astro-cid-muwqkpis]{color:var(--body-color);font-variant-numeric:tabular-nums;font-weight:560}input[data-astro-cid-muwqkpis][type=range]{width:100%;accent-color:var(--body-color)}.truth[data-astro-cid-muwqkpis]{background:var(--body-bg);color:var(--body-color);white-space:nowrap;box-shadow:inset 0 0 0 1px var(--hairline);border-radius:1rem;padding:.25rem .625rem;font-size:.75rem;font-weight:500}.truth[data-astro-cid-muwqkpis]:hover{box-shadow:inset 0 0 0 1px var(--muted)}.truth[data-astro-cid-muwqkpis]:focus-visible{outline:2px solid var(--focus-color);outline-offset:1px}svg[data-astro-cid-muwqkpis]{background:var(--body-bg);width:100%;height:auto;box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.5rem;margin-top:.75rem;display:block}svg[data-astro-cid-muwqkpis] .cand{fill:var(--body-color);opacity:calc(.15 + var(--q) * .75)}svg[data-astro-cid-muwqkpis] .ring{fill:none;stroke:rgb(var(--pick));stroke-width:.7px}svg[data-astro-cid-muwqkpis] .order{fill:rgb(var(--pick));font-size:3px;font-weight:600}svg[data-astro-cid-muwqkpis] .star{fill:var(--body-color)}svg[data-astro-cid-muwqkpis] .link{stroke:var(--muted);stroke-width:.4px;stroke-dasharray:1 1}.result[data-astro-cid-muwqkpis]{color:var(--muted);flex-wrap:wrap;align-items:center;gap:.375rem 1rem;padding-top:.625rem;font-size:.6875rem;font-weight:460;display:flex}.legend[data-astro-cid-muwqkpis]{align-items:center;gap:.3125rem;display:flex}.key[data-astro-cid-muwqkpis]{border-radius:50%;width:.5rem;height:.5rem}.key[data-astro-cid-muwqkpis].quality{background:linear-gradient(90deg, var(--hairline), var(--body-color))}.key[data-astro-cid-muwqkpis].picked{box-shadow:inset 0 0 0 1.5px rgb(var(--pick))}.score[data-astro-cid-muwqkpis]{color:var(--soft);font-variant-numeric:tabular-nums;margin-left:auto;font-size:.75rem}.score[data-astro-cid-muwqkpis] strong{color:var(--body-color)}.score[data-astro-cid-muwqkpis] span{color:var(--muted)}.diversity[data-astro-cid-peewoycl]{--variant:42, 120, 214;background:var(--pre-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.75rem;padding:1rem}:root[data-theme=dark] .diversity[data-astro-cid-peewoycl]{--variant:57, 135, 229}.toolbar[data-astro-cid-peewoycl]{flex-wrap:wrap;align-items:center;gap:.375rem;display:flex}.toolbar[data-astro-cid-peewoycl] button[data-astro-cid-peewoycl]{background:var(--body-bg);color:var(--body-color);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:1rem;padding:.25rem .625rem;font-size:.75rem;font-weight:500;transition:box-shadow .15s}.toolbar[data-astro-cid-peewoycl] button[data-astro-cid-peewoycl]:hover{box-shadow:inset 0 0 0 1px var(--muted)}.toolbar[data-astro-cid-peewoycl] button[data-astro-cid-peewoycl]:focus-visible{outline:2px solid var(--focus-color);outline-offset:1px}.toolbar[data-astro-cid-peewoycl] .quiet[data-astro-cid-peewoycl]{color:var(--muted);box-shadow:none;background:0 0}.readout[data-astro-cid-peewoycl]{color:var(--muted);font-variant-numeric:tabular-nums;margin-left:auto;font-size:.75rem;font-weight:460}.view[data-astro-cid-peewoycl]{aspect-ratio:1;cursor:grab;touch-action:none;width:100%;max-width:16rem;height:auto;margin:.5rem auto 0;display:block;overflow:visible}.view[data-astro-cid-peewoycl]:active{cursor:grabbing}.view[data-astro-cid-peewoycl] .seg{stroke-width:.8px;stroke-linecap:round}.view[data-astro-cid-peewoycl] .original{stroke:var(--bullet);fill:var(--bullet)}.view[data-astro-cid-peewoycl] .variant{stroke:rgb(var(--variant));fill:rgb(var(--variant))}.view[data-astro-cid-peewoycl] .dot{stroke:var(--pre-bg);stroke-width:.3px}@media (width<=560px){.readout[data-astro-cid-peewoycl]{width:100%;margin-left:0}}.planner[data-astro-cid-rrcnbvxe]{--tbm:42, 120, 214;--model:27, 175, 122;background:var(--pre-bg);box-shadow:inset 0 0 0 1px var(--hairline);border-radius:.75rem;padding:1rem}:root[data-theme=dark] .planner[data-astro-cid-rrcnbvxe]{--tbm:57, 135, 229;--model:25, 158, 112}.controls[data-astro-cid-rrcnbvxe]{grid-template-columns:1fr 1fr;gap:1.25rem;padding-bottom:1rem;display:grid}label[data-astro-cid-rrcnbvxe]{flex-direction:column;gap:.375rem;display:flex}label[data-astro-cid-rrcnbvxe]>span[data-astro-cid-rrcnbvxe]{color:var(--soft);justify-content:space-between;font-size:.75rem;font-weight:460;display:flex}output[data-astro-cid-rrcnbvxe]{color:var(--body-color);font-variant-numeric:tabular-nums;font-weight:560}input[data-astro-cid-rrcnbvxe][type=range]{width:100%;accent-color:var(--body-color)}.slots[data-astro-cid-rrcnbvxe]{grid-template-columns:repeat(5,1fr);gap:.375rem;padding-bottom:1rem;display:grid}.slot[data-astro-cid-rrcnbvxe]{--tone:var(--model);background:rgba(var(--tone), .1);box-shadow:inset 0 0 0 1.5px rgba(var(--tone), .7);border-radius:.5rem;flex-direction:column;align-items:center;gap:.125rem;padding:.5rem .25rem;transition:background .2s,box-shadow .2s;display:flex}.slot[data-astro-cid-rrcnbvxe][data-kind=tbm]{--tone:var(--tbm)}.slot-n[data-astro-cid-rrcnbvxe]{color:var(--muted);font-size:.625rem;font-weight:500}.slot-kind[data-astro-cid-rrcnbvxe]{color:var(--body-color);font-size:.75rem;font-weight:560}.phases[data-astro-cid-rrcnbvxe]{counter-reset:phase;flex-direction:column;gap:.375rem;display:flex}.phases[data-astro-cid-rrcnbvxe] li[data-astro-cid-rrcnbvxe]{background:var(--body-bg);box-shadow:inset 0 0 0 1px var(--hairline);counter-increment:phase;border-radius:.5rem;padding:.5rem .75rem .5rem 2rem;transition:opacity .2s;position:relative}.phases[data-astro-cid-rrcnbvxe] li[data-astro-cid-rrcnbvxe]:before{content:counter(phase);color:var(--muted);font-size:.75rem;font-weight:560;line-height:1.25rem;position:absolute;top:.5rem;left:.75rem}.phases[data-astro-cid-rrcnbvxe] li[data-astro-cid-rrcnbvxe][data-skipped]{opacity:.45}.name[data-astro-cid-rrcnbvxe]{color:var(--body-color);justify-content:space-between;gap:.75rem;display:flex;padding:0!important;font-size:.8125rem!important;font-weight:560!important}.status[data-astro-cid-rrcnbvxe]{color:var(--muted);text-align:right;font-size:.75rem;font-weight:460}.detail[data-astro-cid-rrcnbvxe]{color:var(--soft);padding:.125rem 0 0!important;font-size:.75rem!important;line-height:1.4!important}@media (width<=560px){.controls[data-astro-cid-rrcnbvxe]{grid-template-columns:1fr;gap:.75rem}.slot-kind[data-astro-cid-rrcnbvxe]{font-size:.6875rem}}